This study aimed to evaluate the optimal timing of taking blood pressure medications. It was designed to evaluate if taking BP medications prior to going to bed had better cardiovascular risk reduction outcomes when compared to ingesting them on waking up in the morning. In the study, , approximately 19,000 hypertensive patients were divided into 2 groups on a 1:1 basis. Ambulatory blood pressure monitoring was performed for 48 hours during each annual clinic visit for a duration of 6.3 years. The.primary CVD outcome (CVD death, myocardial infarction, coronary revascularization, heart failure, or stroke) were monitored.Patients of the bedtime, compared with the upon-waking, treatment-time regimen showed significantly lower hazard ratio after adjusting for other various influential characteristics. The study concluded that intake of blood pressure medications of greater than 1 prescribed BP lowering medication at that time resulted in significant lower ambulatory blood pressure readings and also decreased occurrence of major cardiovascular events.
